DCDT+ Revision history:
Version 2.5.1 (dated 09/26/2019)
bug fixes:
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Fixed problem with sizing of the rich text panel in the Log page
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Fixed problem where the clicking on the Navigation Tree was not always moving to
the desired analysis page
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Fixed problem with unneeded Log entries resulting from the 'Adjust Parameter
Upper/Lower Limits' procedure
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Fixed problem with unneeded Log entries about despiking
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Version 2.4.3 (dated 10/7/2014)
bug fixes:
| fixed bug in the bootstrap routine causing incorrect computation of the
parameter standard deviations and therefore the confidence intervals (this bug
was only relevant when the 'computed standard deviation of parameter
distribution' option was selected rather than 'observed parameter
frequencies') |
Version 2.4.3 (dated 08/27/2014)
bug fixes:
| fixed bug in parameter precision testing for species concentrations
causing fitting to terminate early (before the true minimum was reached) |
| fixed bug in the graph scaling dialog (after double-clicking on an axis)
where the graph did not refresh with the desired the new scaling |
Version 2.4.1 (dated 09/04/2013)
enhancements: registration is no longer required
Version 2.4.0 (dated 07/22/2012)
enhancements:
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added automatic recording of all analysis procedures to a Log page
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added new buttons to insert graphs into the Log to the 'Graph fit results' page
and the bootstrap/Monte Carlo graphs dialog
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axis scaling and tick mark intervals can now be customized by clicking directly
on the corresponding axis
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added a new 'summary plot' to 'Graph fit results' page
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the fit report now uses the summary plot
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bug fixes:
| when absorbance intensity data are converted during loading to true
absorbance or pseudo-absorbance the file names are now correctly shown with
the .ra_ extension rather than .ri_ |
Version 2.3.4 (dated 03/20/2012)
bug fixes:
| fixed problems with installation and registration |
Version 2.3.3 (dated 03/18/2012)
enhancements:
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added fluorescence data type to Claverie simulation form
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bug fixes:
| fixed problem with Edit..Copy of dc/dt data for all scan pairs |
| fixed problem with turning off display of the Toolbar and/or Navigation
Panel |
| fixed problem with jitter correction for multi-section dc/dt |
| fixed problem with incorrect recognition of interference and fluorescence
scan types for simulated data |
| fixed problem with cloning of a new copy when a file is opened that is
already open |
| fixed problem with correct display of cell number in cloned analysis
windows |
| fixed problem in Claverie simulation form when meniscus position was moved
to less than the radius of the top of the cell |
Version 2.3.2 (dated 10/3/2010)
enhancements:
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added ability to graph sample temperature versus elapsed run time |
bug fixes:
| fixed a problem during confidence interval evaluation using F statistics
with the display of the current phase and remaining time |
| fixed a problem with setting the file open dialog to the last folder used
for data loading |
Version 2.3.1 (dated 9/7/2010)
bug fixes:
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attempting to copy a report containing a graph to the Clipboard caused a crash
if the current report printer (as set by the Program Options dialog) was not
connected
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attempting to set a default report printer (Program Options dialog) caused a
crash if the selected printer was not currently valid
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the bootstrap or Monte Carlo confidence limit routines were sometimes halting
with 'index out of range' errors for fits using interference data
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Version 2.3.0 (dated 9/4/2010)
enhancements:
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new, much improved report formatting, with the option to copy the entire report
to the Clipboard as rich text for pasting into a word processor or electronic
lab notebook
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added two new methods for confidence interval computation (bootstrap with
replacement and Monte Carlo), and a new button to graph the parameter
distributions resulting from those calculations
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added ability to split the scan group used in computing dc/dt into
multiple sections to reduce the peak spreading (this should be used only
if the g(s*) distribution is going to be fitted)
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the raw scans graph is now displayed using a rainbow spectrum of colors when the
number of scans exceeds 40 (when there are too many scans to visually identify
individual ones via the combination of color and line style); as before, the
graph legend is also suppressed when there are more than 40 scans displayed
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during scan loading files created and used by SEDFIT such as "list.ra1",
"sdist.ra1", or "~tmppars.ra1" are ignored (not read). Thus in scan pre-select
mode, if you want to load all scans for that cell and scan type, in the File
Open dialog first click on any scan, hit "CTRL-A" on the keyboard to highlight
all the scans, and then hit 'Enter' or click 'Open".
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on the fit results page the sedimentation or diffusion coefficients are now
labeled as 's(20,w)' or 'D(20,w)' when that is needed
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bug fixes:
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the program will now work correctly on 64-bit versions of Windows7 (this was a
problem in the 3rd-party graphing package used by DCDT+)
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fixed problem on the 'Select scans' page where the automatic x-axis point
spacing for the average dc/dt curve was not updating as the scan selection
changed
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fixed problem where opening the mass/diffusion calculator was changing the
solvent density back to the default value
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fixed problems with rounding of the g(s*) curve x-axis point spacing when in
s(20,w) mode
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fixed control location problems on the Fitting Parameters monitor tab of the Fit
Monitor page
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the 'Save this analysis' context menu item in the Analysis Page right-click
context menu was not doing anything
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worked on problems with inappropriate display of wait cursor over controls on
parameter guesses page and fitting parameters monitor
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Version 2.2.1 (dated 1/17/2009)
enhancements:
| changed the behavior of the Fit Monitor to force display of the current parameters
tab whenever a parameter goes out of bounds (to better alert the user to this
condition) |
bug fixes:
| fixed errors in parameter guess display when the number of active parameters
decreases |
| fixed errors in derivatives when parameters were constrained (this only
affected the rate of convergence) |
| fixed bug when the 'Add more scans' button was used to add files that were
already loaded |
| fixed bug when saving/restored unweighted fits |
| fixed bug in exporting data using the Edit...copy scan graph data command |
| fixed bug in the Claverie simulator dialog box that would not allow changing
the number of data points spanning the cell |
Version 2.2.0 (dated 7/18/2008)
enhancements:
| new option for mass constraints calculates constrained mass value assuming
the linked species have the same shape (constant f/f0 ratio,
as in SEDFIT c(s) method) |
| on the 'Set/Alter fitting parameters' page now only the parameters that
are active (fitted, held fixed, or constrained) are shown; parameters for
species that are not active are not displayed |
| added ability to customize axis labels for all graphs (by clicking on the
label). Graph titles can also be edited by clicking on them (although they can
also still be edited from the Graph Customization dialog box) |
| added new Options and Help buttons to the Toolbar |
| created Tools menu with entries for the Mass/Diffusion calculator and the
Program Options dialog to make menus conform to standard MS conventions |
| added a new right-click context menu for the the Navigation Panel |
| the position of the splitter defining the width of the Navigation Panel is
now saved |
| a new right-click context menu allows the panel holding the Next/Back,
More/Less, and status line to optionally be moved to the top of the analysis
window, closer to the other buttons and controls |
| when a command is issued that will close more than 2 un-saved analysis
windows, rather than asking whether to save each one a new dialog with 'save
all' and 'save none' options is displayed. |
| upgraded user interface components to .NET 2.0 for better standard
Microsoft look and feel |
| better formatting of printed manual |
bug fixes:
| fixed problem with positioning of fit range markers on the 'Set initial
guesses on graph' page when the fit range was altered using the text boxes and
when working in s(20,w) units |
| fixed problem on the 'Calculate g(s*) distribution' page where turning
s(20,w) units on or off disabled the Next button |
| fixed crash that occurred if you attempted to switch to a different
analysis window while the program was computing confidence limits (main window
and all analysis windows are now disabled during this computation) |
| changed reporting of high parameter cross-correlation so that parameters
exceeding the 'very high' threshold are not also counted and reported as
'high' values |
Version 2.1.0 (dated 12/30/2007)
bug fix:
| fixed problems related to use of Windows Regional Settings that specify a
decimal separator other than "." |
Version 2.0.9 (dated 6/3/2007)
enhancements:
| The right-click context menu for all graphs now includes an option to
readout the mouse position to allow reading data values from the graphs. The
X,Y values are displayed in the upper right corner. |
bug fixes:
| fixed version 2.0.8 problem preventing reading of analyses that had been
saved as .dcdt files by that version |
| the version 2.0.8 installation file did not include a file that is needed
for running Claverie simulations |
Version 2.0.8 (dated 4/29/2007)
enhancements/revisions:
| scan loading now continues after a bad scan file is skipped |
| the test for bad scan files during loading was revised to warn for less than 50 data points
rather than <10; this test can optionally be turned off after first warning if you
really do have experiments with less than 50 data points |
| mass/diffusion calculator menu item moved to View menu |
bug fixes:
| fixed problem with right-click display of scan header info on scan load
page (wrong scan was sometimes displayed) |
| fixed extra tab characters when data copied to clipboard |
| fixed insufficient decimal places to show difference between upper and
lower confidence limits on Report Fit page |
| Gigasoft graphing package update fixes extraneous lines issue with
exported metafiles |
Version 2.0.7 (dated 9/23/2006)
bug fixes:
| fixed problems with integrating regions of the g(s*) distribution when in
s20,w units |
| fixed crash that sometimes occurred when switching to the broad g(s*)
algorithm while in s20,w units |
| fixed incorrect display of Advanced mode when restoring an analysis saved
while in the Advanced mode |
| updated Help file to correct bad links in image hotspots |
Version 2.0.6 (dated 8/15/2006)
enhancements:
| now optionally writes out data from intensity scans after conversion to
true absorbance or pseudo-absorbance |
bug fixes:
| fixed bug when printing parameter standard error in fit report (bug was
not present for true confidence limits) |
| fixed problem with saving un-saved files when closing program |
| fixed problem with automatic jitter correction not always being
automatically applied |
| fixed problem with installation program that produced the need to
un-install before upgrading |
Version 2.0.5 (dated 5/14/2006)
enhancements:
| revised and updated Help file and manual |
bug fixes:
| altered printing of reports to eliminate need for writing temporary files,
which was causing problems for users on restricted accounts |
| fixed improper sizing of analysis window when it was maximized |
| fixed false error message after program registration saying that the
information had not been stored |
Version 2.0.4 (dated 3/28/2006)
enhancements:
| items were added to the Edit menu for directly writing out data as text files
(without passing through the Clipboard) |
| after manual dragging of the meniscus position for absorbance scans you are
now asked whether the wizard should re-calculate the average position of the
positive spike in all the scans and place the meniscus there (this is for use
when the meniscus wizard fails to find the correct spike) |
| the behavior of the Set Meniscus and Data Region graph was altered to
improve responsiveness during position marker drags (which was poor when large
numbers of interference scans were loaded). To avoid repeated graph redrawing,
the original position of the marker remains displayed while you drag the bold
version of that marker; the final position is updated on the graph at the end
of the drag operation |
| the absorbance data de-spiking routine now ignores the region near the
meniscus so the meniscus spike is not recognized or altered |
| you can now use use jitter correction for pseudo-absorbance data (two
samples per cell), which seems to be necessary |
| scientific notation is now used for graph tick mark labels when data
values are < 0.0001 or > 100000 |
| new entries on the graph right-click pop-up menu were added for
- controlling whether the axis ranges are rounded after a zoom operation
(rounding limits the maximum effective zoom that can be reached)
- printing the graph to the Windows default printer (full page, landscape
orientation) without
going through the Export dialog
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bug fixes:
| fixed problem with reading of pseudo-absorbance data (two samples per
cell) causing vertical shifts between scans |
| fixed problem that reports did not indicate which channel
pseudo-absorbance data came from |
| fixed bug that changing back and forth from s(20,w) units failed to set
flags that this forced re-calculation of the dc/dt and g(s*)
data (because it usually changes the spacing between data points) and thus the
fit needs to be re-done |
| fixed bug when using Enter key to terminate editing of legend text for
g(s*) overlay graph |
| fixed bug causing spurious warnings that saved analysis files were from a
newer version of the program |
| cleaned up some remaining sizing and formatting issues with analysis form |
Version 2.0.3 (dated 3/4/2006)
Fixed problems with multiple users on one computer. Re-worked installation,
added reminder regarding installing "For everyone".
Version 2.0.2 (dated 2/25/2006)
Fixed bug causing parameter cross-correlations above the 'very high'
threshold to be flagged in the correlation table as only 'high'.
Version 2.0.1 (dated 2/22/2006)
enhancements:
| added items to the Edit menu for copying of dc/dt data for all scan pairs, and
copying of the data from the scan graph (after correction for jitter and
fringe jumps if desired) |
bug fixes:
| fixed problem with font sizing on forms for users with Display setting at
'Normal' (96 dpi) fonts rather than 'Large' (120 dpi) fonts |
| improved legibility of cross-correlation matrix display |
| fixed bug causing attempts to access floppy drive when saved analysis
documents are restored |
| fixed improper printout of constraint parameters on reports |
| moved location of temporary files created during printing of reports to
eliminate problem for users with restricted file access privileges |
| moved location of registration information so a single 'administrative'
installation should work for computers with multiple users |
Version 2.0.0 (dated 02/06/2006)
First release of major upgrade:
| entirely new user interface |
| multiple analysis documents open simultaneously |
| g(s*) overlay graphs for comparing different samples |
| new fitting algorithm eliminates systematic errors in hydrodynamic
properties; accuracy 0.1% or better |
Version 1.16 (dated 09/14/2002)
enhancements:
| added rotor speed, experimental temperature, and wavelength to reports |
| revised and updated Help file |
bug fixes:
| finished implementation of user-determined parameter precision as
alternate criterion for convergence of fit |
Version 1.15 (dated 03/13/2002)
bug fixes:
| fixed problem in interpolating dc/dt curves to uniform grid of
sedimentation coefficients during calculation of average dc/dt curve |
Version 1.14 (dated 01/06/2001)
enhancements:
| Claverie simulations of absorbance scans now default to 601 radial points
to better match the typical number of points actually taken when using the
default 0.003 cm nominal spacing |
| improved detection of fit convergence |
bug fixes:
| fixed problem sometimes causing a re-calculation of the dc/dt data after
re-setting the meniscus to the same value (a round-off error problem) |
| fixed crash if the fitting model was switched from fitting dc/dt
data to fitting g(s*) but g(s*) had not yet been calculated |
| fixed problem with using constraints on properties of species #5 |
| fixed problem with turning off one (but not all) constraints |
| fixed display problem with confidence level dialog box |
| fixed problem that user-supplied Comment lines for Claverie simulations
were being written to the disk files but not stored in internal memory |
| fixed minor problems in calculating derivatives when fitting to mass
rather than D |
Version 1.13 (dated 07/15/2000)
enhancements:
| improved accuracy for graphical setting of meniscus |
bug fixes:
| fixed bug in restoring preferred default folder for saved fits |
Version 1.12 (dated 03/05/2000)
bug fixes:
| fixed error in calculating temperature correction to vbar for use in
conversion to s20,w |
Version 1.11 (dated 02/26/2000)
bug fixes:
| fixed bug in restoring fits saved with version 1.10 when conversion to s20,w
was active |
Version 1.10 (dated 02/06/2000)
enhancements:
| optional new algorithm for calculating g(s*) distributions giving
improved estimates of error bars and some improvement in fit accuracy when
the time span of the data grows long |
| ability to copy all parameters from the Calculate Mass or D form to the
Clipboard |
bug fixes:
| fixed bug in conversion of raw D values to D20,w |
| fixed bugs in the Calculate Mass or D form
 | solvent density was being replaced with that of water when conversion
to s20,w was active |
| the user could still alter the temperature and density even when
conversion to s20,w was active |
| the masses from the last fit were not being loaded properly when s/D
mass units were in use |
| 'type mismatch' errors were causing crashes |
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| fixed minor formatting problems in fit reports |
Version 1.05 (dated 11/26/99)
enhancements:
| new Preferences items for setting default folders for scan files and saved
results |
| the user preferences for the decimal indicator ( . versus , ), as
established by Windows® Control Panel settings, are now obeyed for user
input and program outputs |
| the Claverie simulator can now create new folders for storing scans
created by the simulation |
bug fixes:
| fixed bug causing minor errors in conversion to s20,w |
| the Claverie form was not properly linked to the Help file |
Version 1.04 (dated 10/09/99), maintenance release
bug fixes:
| fixed problems with conversion from raw s to s20,w
| manually-entered values of vbar at 20 C were not being
displayed when the dialog box was redisplayed |
| saved fit files did not contain all the information
needed to perform the conversion upon reloading |
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| altered logic defining convergence to take care of occasional failures to
detect that convergence has occurred |
| the Help file was updated |
Version 1.03 (dated 9/23/99), maintenance release
| the sedimentation coefficient interval, delta-s, may now be as large as
5000 S, allowing analysis of samples containing species up to ~5 x 106
S. |
| fit results and data graphs are now cleared if you change vbar, solvent
density, or other values that alter
units conversions |
| the menu status is now properly updated when the program is started by
double-clicking on a .fit file |
| a work-around has been implemented for a Windows NT-specific error after
saving .fit files |
| the Help file has been updated |
Version 1.02 (dated 8/24/99), maintenance release
| implemented work-around for a bug in a purchased external support
file causing intermittent crashes during the 'Set Range of s values for
fitting' routine |
Version 1.01 (dated 8/21/99)
enhancements:
| added gauge to show progress during calculation of average dc/dt |
bug fixes:
| corrected errors in calculated uncertainty of weight-, z-, and z+1-average
sedimentation coefficients; Help modified to show current formulae |
| corrected Y axis label on graph when setting range for calculating g(s*) |
| fixed bug leaving species 1 inactive during the first fit after restoring
a .fit file that contained only g(s*) curves but no actual fit |
| the 'test time span for broadening' and average sedimentation coefficient
forms are now modal |
Original release version 1.00, dated 7/24/99
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