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DCDT+ Revision history:

Version 2.4.3 (dated 10/7/2014)

bug fixes:

bulletfixed bug in the bootstrap routine causing incorrect computation of the parameter standard deviations and therefore the confidence intervals (this bug was only relevant when the 'computed standard deviation of parameter distribution' option was selected rather than 'observed parameter frequencies')

Version 2.4.3 (dated 08/27/2014)

bug fixes:

bulletfixed bug in parameter precision testing for species concentrations causing fitting to terminate early (before the true minimum was reached)
bulletfixed bug in the graph scaling dialog (after double-clicking on an axis) where the graph did not refresh with the desired the new scaling

Version 2.4.1 (dated 09/04/2013)

enhancements: registration is no longer required

Version 2.4.0 (dated 07/22/2012)

enhancements:

bullet

added automatic recording of all analysis procedures to a Log page

bullet

added new buttons to insert graphs into the Log to the 'Graph fit results' page and the bootstrap/Monte Carlo graphs dialog

bullet

axis scaling and tick mark intervals can now be customized by clicking directly on the corresponding axis

bullet

added a new 'summary plot' to 'Graph fit results' page

bullet

the fit report now uses the summary plot

bug fixes:

bulletwhen absorbance intensity data are converted during loading to true absorbance or pseudo-absorbance the file names are now correctly shown with the .ra_ extension rather than .ri_

Version 2.3.4 (dated 03/20/2012)

bug fixes:

bulletfixed problems with installation and registration

Version 2.3.3 (dated 03/18/2012)

enhancements:

bullet

added fluorescence data type to Claverie simulation form

bug fixes:

bulletfixed problem with Edit..Copy of dc/dt data for all scan pairs
bulletfixed problem with turning off display of the Toolbar and/or Navigation Panel
bulletfixed problem with jitter correction for multi-section dc/dt
bulletfixed problem with incorrect recognition of interference and fluorescence scan types for simulated data
bulletfixed problem with cloning of a new copy when a file is opened that is already open
bulletfixed problem with correct display of cell number in cloned analysis windows
bulletfixed problem in Claverie simulation form when meniscus position was moved to less than the radius of the top of the cell

 

Version 2.3.2 (dated 10/3/2010)

enhancements:

bullet

added ability to graph sample temperature versus elapsed run time

bug fixes:

bulletfixed a problem during confidence interval evaluation using F statistics with the display of the current phase and remaining time
bulletfixed a problem with setting the file open dialog to the last folder used for data loading

 

Version 2.3.1 (dated 9/7/2010)

bug fixes:

bullet

attempting to copy a report containing a graph to the Clipboard caused a crash if the current report printer (as set by the Program Options dialog) was not connected

bullet

attempting to set a default report printer (Program Options dialog) caused a crash if the selected printer was not currently valid

bullet

the bootstrap or Monte Carlo confidence limit routines were sometimes halting with 'index out of range' errors for fits using interference data

 

Version 2.3.0 (dated 9/4/2010)

enhancements:

bullet

new, much improved report formatting, with the option to copy the entire report to the Clipboard as rich text for pasting into a word processor or electronic lab notebook

bullet

added two new methods for confidence interval computation (bootstrap with replacement and Monte Carlo), and a new button to graph the parameter distributions resulting from those calculations

bullet

added ability to split the scan group used in computing dc/dt into multiple sections to reduce the peak spreading (this should be used only if the g(s*) distribution is going to be fitted)

bullet

the raw scans graph is now displayed using a rainbow spectrum of colors when the number of scans exceeds 40 (when there are too many scans to visually identify individual ones via the combination of color and line style); as before, the graph legend is also suppressed when there are more than 40 scans displayed

bullet

during scan loading files created and used by SEDFIT such as "list.ra1", "sdist.ra1", or "~tmppars.ra1" are ignored (not read). Thus in scan pre-select mode, if you want to load all scans for that cell and scan type, in the File Open dialog first click on any scan, hit "CTRL-A" on the keyboard to highlight all the scans, and then hit 'Enter' or click 'Open".

bullet

on the fit results page the sedimentation or diffusion coefficients are now labeled as 's(20,w)' or 'D(20,w)' when that is needed

bug fixes:

bullet

the program will now work correctly on 64-bit versions of Windows7 (this was a problem in the 3rd-party graphing package used by DCDT+)

bullet

fixed problem on the 'Select scans' page where the automatic x-axis point spacing for the average dc/dt curve was not updating as the scan selection changed

bullet

fixed problem where opening the mass/diffusion calculator was changing the solvent density back to the default value

bullet

fixed problems with rounding of the g(s*) curve x-axis point spacing when in s(20,w) mode

bullet

fixed control location problems on the Fitting Parameters monitor tab of the Fit Monitor page

bullet

the 'Save this analysis' context menu item in the Analysis Page right-click context menu was not doing anything

bullet

worked on problems with inappropriate display of wait cursor over controls on parameter guesses page and fitting parameters monitor
 

Version 2.2.1 (dated 1/17/2009)

enhancements:

bulletchanged the behavior of the Fit Monitor to force display of the current parameters tab whenever a parameter goes out of bounds (to better alert the user to this condition)

bug fixes:

bulletfixed errors in parameter guess display when the number of active parameters decreases
bulletfixed errors in derivatives when parameters were constrained (this only affected the rate of convergence)
bulletfixed bug when the 'Add more scans' button was used to add files that were already loaded
bulletfixed bug when saving/restored unweighted fits
bulletfixed bug in exporting data using the Edit...copy scan graph data command
bulletfixed bug in the Claverie simulator dialog box that would not allow changing the number of data points spanning the cell

Version 2.2.0 (dated 7/18/2008)

enhancements:

bulletnew option for mass constraints calculates constrained mass value assuming the linked species have the same shape (constant f/f0 ratio, as in SEDFIT c(s) method)
bulleton the 'Set/Alter fitting parameters' page now only the parameters that are active (fitted, held fixed, or constrained) are shown; parameters for species that are not active are not displayed
bulletadded ability to customize axis labels for all graphs (by clicking on the label). Graph titles can also be edited by clicking on them (although they can also still be edited from the Graph Customization dialog box)
bulletadded new Options and Help buttons to the Toolbar
bulletcreated Tools menu with entries for the Mass/Diffusion calculator and the Program Options dialog to make menus conform to standard MS conventions
bulletadded a new right-click context menu for the the Navigation Panel
bulletthe position of the splitter defining the width of the Navigation Panel is now saved
bulleta new right-click context menu allows the panel holding the Next/Back, More/Less, and status line to optionally be moved to the top of the analysis window, closer to the other buttons and controls
bulletwhen a command is issued that will close more than 2 un-saved analysis windows, rather than asking whether to save each one a new dialog with 'save all' and 'save none' options is displayed.
bulletupgraded user interface components to .NET 2.0 for better standard Microsoft look and feel
bulletbetter formatting of printed manual

bug fixes:

bulletfixed problem with positioning of fit range markers on the 'Set initial guesses on graph' page when the fit range was altered using the text boxes and when working in s(20,w) units
bulletfixed problem on the 'Calculate g(s*) distribution' page where turning s(20,w) units on or off disabled the Next button
bulletfixed crash that occurred if you attempted to switch to a different analysis window while the program was computing confidence limits (main window and all analysis windows are now disabled during this computation)
bulletchanged reporting of high parameter cross-correlation so that parameters exceeding the 'very high' threshold are not also counted and reported as 'high' values

Version 2.1.0 (dated 12/30/2007)

bug fix:

bulletfixed problems related to use of Windows Regional Settings that specify a decimal separator other than "."

Version 2.0.9 (dated 6/3/2007)

enhancements:

bulletThe right-click context menu for all graphs now includes an option to readout the mouse position to allow reading data values from the graphs. The X,Y values are displayed in the upper right corner.

bug fixes:

bulletfixed version 2.0.8 problem preventing reading of analyses that had been saved as .dcdt files by that version
bulletthe version 2.0.8 installation file did not include a file that is needed for running Claverie simulations

Version 2.0.8 (dated 4/29/2007)

enhancements/revisions:

bulletscan loading now continues after a bad scan file is skipped
bulletthe test for bad scan files during loading was revised to warn for less than 50 data points rather than <10; this test can optionally be turned off after first warning if you really do have experiments with less than 50 data points
bulletmass/diffusion calculator menu item moved to View menu

bug fixes:

bulletfixed problem with right-click display of scan header info on scan load page (wrong scan was sometimes displayed)
bulletfixed extra tab characters when data copied to clipboard
bulletfixed insufficient decimal places to show difference between upper and lower confidence limits on Report Fit page
bulletGigasoft graphing package update fixes extraneous lines issue with exported metafiles

Version 2.0.7 (dated 9/23/2006)

bug fixes:

bulletfixed problems with integrating regions of the g(s*) distribution when in s20,w units
bulletfixed crash that sometimes occurred when switching to the broad g(s*) algorithm while in s20,w units
bulletfixed incorrect display of Advanced mode when restoring an analysis saved while in the Advanced mode
bulletupdated Help file to correct bad links in image hotspots

Version 2.0.6 (dated 8/15/2006)

enhancements:

bulletnow optionally writes out data from intensity scans after conversion to true absorbance or pseudo-absorbance

bug fixes:

bulletfixed bug when printing parameter standard error in fit report (bug was not present for true confidence limits)
bulletfixed problem with saving un-saved files when closing program
bulletfixed problem with automatic jitter correction not always being automatically applied
bulletfixed problem with installation program that produced the need to un-install before upgrading

Version 2.0.5 (dated 5/14/2006)

enhancements:

bulletrevised and updated Help file and manual

bug fixes:

bulletaltered printing of reports to eliminate need for writing temporary files, which was causing problems for users on restricted accounts
bulletfixed improper sizing of analysis window when it was maximized
bulletfixed false error message after program registration saying that the information had not been stored

 

Version 2.0.4 (dated 3/28/2006)

enhancements:

bulletitems were added to the Edit menu for directly writing out data as text files (without passing through the Clipboard)
bulletafter manual dragging of the meniscus position for absorbance scans you are now asked whether the wizard should re-calculate the average position of the positive spike in all the scans and place the meniscus there (this is for use when the meniscus wizard fails to find the correct spike)
bulletthe behavior of the Set Meniscus and Data Region graph was altered to improve responsiveness during position marker drags (which was poor when large numbers of interference scans were loaded). To avoid repeated graph redrawing, the original position of the marker remains displayed while you drag the bold version of that marker; the final position is updated on the graph at the end of the drag operation
bulletthe absorbance data de-spiking routine now ignores the region near the meniscus so the meniscus spike is not recognized or altered
bulletyou can now use use jitter correction for pseudo-absorbance data (two samples per cell), which seems to be necessary
bulletscientific notation is now used for graph tick mark labels when data values are < 0.0001 or > 100000
bulletnew entries on the graph right-click pop-up menu were added for
  1. controlling whether the axis ranges are rounded after a zoom operation (rounding limits the maximum effective zoom that can be reached)
  2. printing the graph to the Windows default printer (full page, landscape orientation) without going through the Export dialog

bug fixes:

bulletfixed problem with reading of pseudo-absorbance data (two samples per cell) causing vertical shifts between scans
bulletfixed problem that reports did not indicate which channel pseudo-absorbance data came from
bulletfixed bug that changing back and forth from s(20,w) units failed to set flags that this forced re-calculation of the dc/dt and g(s*) data (because it usually changes the spacing between data points) and thus the fit needs to be re-done
bulletfixed bug when using Enter key to terminate editing of legend text for g(s*) overlay graph
bulletfixed bug causing spurious warnings that saved analysis files were from a newer version of the program
bulletcleaned up some remaining sizing and formatting issues with analysis form

Version 2.0.3 (dated 3/4/2006)

Fixed problems with multiple users on one computer. Re-worked installation, added reminder regarding installing "For everyone".

Version 2.0.2 (dated 2/25/2006)

Fixed bug causing parameter cross-correlations above the 'very high' threshold to be flagged in the correlation table as only 'high'.

Version 2.0.1 (dated 2/22/2006)

enhancements:

bulletadded items to the Edit menu for copying of dc/dt data for all scan pairs, and copying of the data from the scan graph (after correction for jitter and fringe jumps if desired)

bug fixes:

bulletfixed problem with font sizing on forms for users with Display setting at  'Normal' (96 dpi) fonts rather than 'Large' (120 dpi) fonts
bulletimproved legibility of cross-correlation matrix display
bulletfixed bug causing attempts to access floppy drive when saved analysis documents are restored
bulletfixed improper printout of constraint parameters on reports
bulletmoved location of temporary files created during printing of reports to eliminate problem for users with restricted file access privileges
bulletmoved location of registration information so a single 'administrative' installation should work for computers with multiple users

Version 2.0.0 (dated 02/06/2006)

First release of major upgrade:

bulletentirely new user interface
bulletmultiple analysis documents open simultaneously
bulletg(s*) overlay graphs for comparing different samples
bulletnew fitting algorithm eliminates systematic errors in hydrodynamic properties; accuracy 0.1% or better

Version 1.16 (dated 09/14/2002)

enhancements:

bulletadded rotor speed, experimental temperature, and wavelength to reports
bulletrevised and updated Help file

bug fixes:

bulletfinished implementation of user-determined parameter precision as alternate criterion for convergence of fit

Version 1.15 (dated 03/13/2002)

bug fixes:

bulletfixed problem in interpolating dc/dt curves to uniform grid of sedimentation coefficients during calculation of average dc/dt curve

Version 1.14 (dated 01/06/2001)

enhancements: 

bulletClaverie simulations of absorbance scans now default to 601 radial points to better match the typical number of points actually taken when using the default 0.003 cm nominal spacing
bulletimproved detection of fit convergence 

bug fixes:

bulletfixed problem sometimes causing a re-calculation of the dc/dt data after re-setting the meniscus to the same value (a round-off error problem)
bulletfixed crash if the fitting model was switched from fitting dc/dt data to fitting g(s*) but g(s*) had not yet been calculated
bulletfixed problem with using constraints on properties of species #5
bulletfixed problem with turning off one (but not all) constraints
bulletfixed display problem with confidence level dialog box
bulletfixed problem that user-supplied Comment lines for Claverie simulations were being written to the disk files but not stored in internal memory
bulletfixed minor problems in calculating derivatives when fitting to mass rather than D

Version 1.13 (dated 07/15/2000)

enhancements: 

bulletimproved accuracy for graphical setting of meniscus 

bug fixes:

bulletfixed bug in restoring preferred default folder for saved fits 

Version 1.12 (dated 03/05/2000)

bug fixes:

bulletfixed error in calculating temperature correction to vbar for use in conversion to s20,w

Version 1.11 (dated 02/26/2000)

bug fixes:

bulletfixed bug in restoring fits saved with version 1.10 when conversion to s20,w was active 

Version 1.10 (dated 02/06/2000)

enhancements: 

bulletoptional new algorithm for calculating g(s*) distributions giving improved estimates of error bars and some improvement in fit accuracy when the time span of the data grows long
bulletability to copy all parameters from the Calculate Mass or D form to the Clipboard

bug fixes:

bulletfixed bug in conversion of raw D values to D20,w 
bulletfixed bugs in the Calculate Mass or D form 
bulletsolvent density was being replaced with that of water when conversion to s20,w was active
bulletthe user could still alter the temperature and density even when conversion to s20,w was active
bulletthe masses from the last fit were not being loaded properly when s/D mass units were in use
bullet'type mismatch' errors were causing crashes
bulletfixed minor formatting problems in fit reports

Version 1.05 (dated 11/26/99)

enhancements: 

bulletnew Preferences items for setting default folders for scan files and saved results
bulletthe user preferences for the decimal indicator ( . versus , ), as established by Windows® Control Panel settings, are now obeyed for user input and program outputs
bulletthe Claverie simulator can now create new folders for storing scans created by the simulation

bug fixes:

bulletfixed bug causing minor errors in conversion to s20,w 
bulletthe Claverie form was not properly linked to the Help file

Version 1.04 (dated 10/09/99), maintenance release

bug fixes: 

bulletfixed problems with conversion from raw s to s20,w
bulletmanually-entered values of vbar at 20 C were not being displayed when the dialog box was redisplayed
bulletsaved fit files did not contain all the information needed to perform the conversion upon reloading
bulletaltered logic defining convergence to take care of occasional failures to detect that convergence has occurred
bulletthe Help file was updated

Version 1.03 (dated 9/23/99), maintenance release

bulletthe sedimentation coefficient interval, delta-s, may now be as large as 5000 S, allowing analysis of samples containing species up to ~5 x 106 S.
bulletfit results and data graphs are now cleared if you change vbar, solvent density, or other values that alter units conversions
bulletthe menu status is now properly updated when the program is started by double-clicking on a .fit file
bulleta work-around has been implemented for a Windows NT-specific error after saving .fit files
bulletthe Help file has been updated

Version 1.02 (dated 8/24/99), maintenance release

bulletimplemented work-around for a bug in a purchased external support file causing intermittent crashes during the 'Set Range of s values for fitting' routine

Version 1.01 (dated 8/21/99)

enhancements: 

bulletadded gauge to show progress during calculation of average dc/dt

bug fixes:

bulletcorrected errors in calculated uncertainty of weight-, z-, and z+1-average sedimentation coefficients; Help modified to show current formulae
bulletcorrected Y axis label on graph when setting range for calculating g(s*)
bulletfixed bug leaving species 1 inactive during the first fit after restoring a .fit file that contained only g(s*) curves but no actual fit
bulletthe 'test time span for broadening' and average sedimentation coefficient forms are now modal

Original release version 1.00, dated 7/24/99